Which year to buy
Best betNo standoutNo year is clearly better than the rest
Newest we'd buy2024The latest year rated a good buy
Avoid2022Far more serious problems than usual
Be careful2021More problems; check the recalls were done
Bar height: serious owner complaints to NHTSA for that year per car on the road, against this model's usual year.
2012GOOD BUYSerious complaints 0.8× usual
13 serious complaints of 14, the most about engine (7) and fuel system (5); per car on the road, 0.8× this model's usual year.
What owners report
“Vehicle cut on fire while sitting lucky outside, the corner of engine passenger side bellow the headlight stores the suspension air pump and electric hydraulic steering pump.. Base on my inspection the ehps heated and set on fire.someone saw the car on fire and called fire dept.. Car was lock and store after hours”
An owner's complaint to NHTSA about the engine, Apr 2021
“There is a strong smell of fuel in the cabin. When I lifted up the rear seats, where the odor is coming from, I see a film of fuel around the fuel sending unit on the driver's side. I lift up the sound insulation and I see fuel that has leaked on total the top of the sending unit.”
An owner's complaint to NHTSA about the fuel system, Jun 2022
14 owner complaints · 0 recalls · EPA combined: 14–21 mpg · NHTSA: Not rated · 2012 trims and features
Every S-Class year's verdict →
Verdicts computed from NHTSA owner complaints, defect investigations and recalls. Cars on the road from New York State registrations. (How we judge.) Data checked 2026-10-06.
Trims and features
Engines: 3.5L 6-cyl hybrid; 4.7L 8-cyl turbo; 5.5L 12-cyl turbo; 5.5L 8-cyl turbo; 6.0L 12-cyl turbo · Drive: 4WD, RWD
2012 S-Class trims
| S350 BLUETEC 4-MATIC | S400 Hybrid | S550 | S550 4-MATIC | S600 Bi-T | S63 AMG | S65 AMG |
|---|
base price, seating and driver-assistance equipment from NHTSA's vehicle database (vPIC), as Mercedes-Benz reports it. Tech and comfort features (CarPlay, heated seats, sunroof) for Mercedes-Benz aren't in our data yet. "—": not verified in our sources. "Varies": standard on some versions of the trim.
Year by year
| Year | Engines | Drive | Fuel economy | Crash rating | Recalls | Owner complaints | Most-reported problem | CarPlay |
|---|---|---|---|---|---|---|---|---|
| 2024 | 3.0L 6-cyl turbo + supercharged, 362–443 hp 4.0L 8-cyl turbo, 496–604 hp 6.0L 12-cyl turbo, 621 hp | AWD | 15–24 mpg | Not rated | 0 | 6 | Electrical system (2) | — |
| 2023 | 3.0L 6-cyl, 362–429 hp 3.0L 6-cyl turbo, 362–429 hp 4.0L 8-cyl turbo, 496–603 hp 6.0L 12-cyl turbo, 621 hp | AWD | 14–23 mpg | Not rated | 0 | 12 | Forward collision avoidance (5) | — |
| 2022 | 3.0L 6-cyl, 362–429 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | AWD | 15–24 mpg | Not rated | 0 | 48 | Forward collision avoidance (17) | — |
| 2021 | 3.0L 6-cyl, 362–429 hp 4.0L 8-cyl turbo, 463–603 hp | 4WD, RWD | 17–24 mpg | Not rated | 0 | 34 | Electrical system (10) | — |
| 2020 | 3.0L 6-cyl turbo, 362 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | 4WD, RWD | 16–23 mpg | Not rated | 1 | 8 | Unknown or other (2) | — |
| 2019 | 3.0L 4-cyl turbo, 362 hp 3.0L 6-cyl turbo, 362 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | 4WD, FWD, RWD | 16–23 mpg | Not rated | 1 | 18 | Unknown or other (5) | — |
| 2018 | 3.0L 6-cyl turbo, 362 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | 4WD, FWD, RWD | 16–22 mpg | Not rated | 1 | 33 | Engine (7) | — |
| 2017 | 3.0L 6-cyl turbo 4.7L 8-cyl turbo, 449 hp 5.5L 8-cyl turbo, 577 hp 6.0L 12-cyl turbo, 621 hp | 4WD, RWD | 16–26 mpg | Not rated | 0 | 22 | Unknown or other (4) | — |
| 2016 | 3.0L 6-cyl turbo 4.7L 8-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 15–26 mpg | Not rated | 0 | 29 | Unknown or other (13) | — |
| 2015 | 3.0L 6-cyl turbo 4.7L 8-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 15–26 mpg | Not rated | 0 | 51 | Unknown or other (10) | — |
| 2014 | 4.7L 8-cyl turbo 5.5L 8-cyl turbo | 4WD, RWD | 18–20 mpg | Not rated | 0 | 25 | Unknown or other (5) | — |
| 2013 | 3.5L 6-cyl hybrid 4.7L 8-cyl turbo 5.5L 12-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 14–21 mpg | Not rated | 0 | 9 | Electrical system (2) | — |
| 2012 | 3.5L 6-cyl hybrid 4.7L 8-cyl turbo 5.5L 12-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 14–21 mpg | Not rated | 0 | 14 | Engine (7) | — |
| 2011 | 3.5L 6-cyl hybrid 5.5L 12-cyl turbo 5.5L 8-cyl 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 14–21 mpg | Not rated | 0 | 19 | Fuel/propulsion system (4) | — |
| 2010 | 3.5L 6-cyl hybrid 5.5L 12-cyl turbo 5.5L 8-cyl 6.0L 12-cyl turbo 6.3L 8-cyl | 4WD, RWD | 13–21 mpg | Not rated | 0 | 34 | Electrical system (10) | — |
Owner complaints are unverified reports to NHTSA, counted as filed: older years have had longer to collect them and sales aren't adjusted for, so see Which year to buy for a fair comparison. Most-reported problem: the component named in the most complaints that year. Sources: EPA, NHTSA, Apple.
Which years have…
Wireless Apple CarPlayApple CarPlay (wired or wireless)Wireless phone chargingHead-up displayPower liftgateLane centeringBlind-spot monitoringHeated front seatsVentilated (cooled) seatsHeated steering wheelLeather seatsRemote startSunroof or moonroofPanoramic roof
Every NHTSA-rated version: crash ratings, safety tech, recalls, complaints
| Year | Version | Stars | Forward collision warning | Lane departure warning | Recalls | Complaints |
|---|---|---|---|---|---|---|
| 2024 | Mercedes-Benz S-Class 4 DR AWD | Not Rated | Standard | Standard | 3 | 6 |
| 2024 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Standard | 3 | 6 |
| 2024 | Mercedes-Benz S-Class PHEV 4 DR AWD | Not Rated | Standard | Standard | 2 | 6 |
| 2023 | Mercedes-Benz Mercedes-Maybach S-Class 4 DR AWD | Not Rated | Standard | Standard | 9 | 11 |
| 2023 | Mercedes-Benz S-Class 4 DR AWD | Not Rated | Standard | Standard | 10 | 12 |
| 2023 | Mercedes-Benz S-Class Hybrid 4 DR AWD | Not Rated | Standard | Standard | 8 | 3 |
| 2022 | Mercedes-Benz Mercedes-Maybach S-Class 4 DR 4WD | Not Rated | Standard | No | 10 | 47 |
| 2022 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | No | 11 | 48 |
| 2022 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | No | 11 | 48 |
| 2021 | Mercedes-Benz S-Class 2 DR RWD | Not Rated | Standard | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | Standard | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | No | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class Cabriolet C RWD | Not Rated | Standard | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class Cabriolet C 4WD | Not Rated | Standard | No | 17 | 34 |
| 2020 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class 2 DR RWD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class Cabriolet C 4WD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class Cabriolet C RWD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | No | No | 4 | 5 |
| 2019 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class 2 DR RWD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class Cabriolet C 4WD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class Cabriolet C RWD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S560e 4 DR RWD | Not Rated | Standard | Optional | 10 | 9 |
| 2018 | Mercedes-Benz S-Class C RWD | Not Rated | Optional | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class C 4WD | Not Rated | Optional | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class Coupe 2 DR 2WD | Not Rated | Optional | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class Coupe 2 DR 4WD | Not Rated | Optional | Optional | 15 | 29 |
| 2017 | Mercedes-Benz S-Class C RWD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class C 4WD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class Hybrid 4 DR 4WD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Optional | Optional | 10 | 22 |
| 2016 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class 2 DR FWD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class Hybrid 4 DR 4WD | Not Rated | Optional | Optional | 7 | 29 |
| 2015 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Optional | 9 | 51 |
| 2015 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | Optional | 9 | 51 |
| 2015 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Standard | Optional | 5 | 11 |
| 2015 | Mercedes-Benz S-Class Hybrid 4 DR 4WD | Not Rated | Standard | Optional | 5 | 11 |
| 2014 | Mercedes-Benz S-CLASS 4 DR 4WD | Not Rated | Standard | Optional | 6 | 25 |
| 2014 | Mercedes-Benz S-CLASS 4 DR RWD | Not Rated | Standard | Optional | 6 | 25 |
| 2013 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Optional | Optional | 0 | 9 |
| 2013 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 0 | 9 |
| 2013 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Optional | No | 0 | 9 |
| 2012 | Mercedes-Benz S-Class 4 DR AWD | Not Rated | Optional | Optional | 3 | 14 |
| 2012 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 3 | 14 |
| 2011 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | No | No | 2 | 19 |
| 2010 | Mercedes-Benz S-Class 4-DR w/SAB | Not Rated | Optional | Optional | 0 | 34 |
Source: NHTSA.
Every EPA-rated version: engines and combined mpg
| Year | EPA model | Engines | Combined |
|---|---|---|---|
| 2024 | Maybach S680 4matic | Auto 9-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2024 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo, Sup Charg | 24 |
| 2024 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2024 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2023 | Maybach S680 4matic | Auto 9-spd, 12 cyl, 6.0 L, Turbo | 14 |
| 2023 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L | 23 |
| 2023 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2023 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2023 | S580e 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 23 |
| 2022 | Maybach S680 4matic | Auto 9-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2022 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L | 24 |
| 2022 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2022 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2021 | AMG S63 4matic Plus Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 17 |
| 2021 | AMG S63 4matic Plus Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2021 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L | 24 |
| 2021 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2021 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2021 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2021 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2020 | AMG S63 4matic Plus | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | AMG S63 4matic Plus Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2020 | AMG S63 4matic Plus Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2020 | Maybach S650 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2020 | S450 | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2020 | S450 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2020 | S560 | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2020 | S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2020 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | S560 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2020 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | S560e | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 23 |
| 2019 | AMG S63 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | AMG S63 4matic Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2019 | AMG S63 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | AMG S65 Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | AMG S65 Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | Maybach S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2019 | Maybach S650 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | S450 | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2019 | S450 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2019 | S560 | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2019 | S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2019 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | S560e | Auto 9-spd, 4 cyl, 3.0 L, Turbo | 23 |
| 2018 | AMG S63 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2018 | AMG S63 4matic Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2018 | AMG S63 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2018 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | AMG S65 Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | AMG S65 Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | Maybach S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2018 | Maybach S650 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | S450 | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2018 | S450 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2018 | S560 | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2018 | S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2018 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2018 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2017 | AMG S63 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2017 | AMG S63 4matic Convertible | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 17 |
| 2017 | AMG S63 4matic Coupe | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2017 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | Maybach S550 4matic | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2017 | Maybach S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | Maybach S650 Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | S550 | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 21 |
| 2017 | S550 4matic | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2017 | S550 4matic Coupe | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2017 | S550 Convertible | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2017 | S550e | Auto 7-spd, 6 cyl, 3.0 L, Turbo | 26 |
| 2017 | S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | S65 AMG Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | S65 AMG Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2016 | AMG S63 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2016 | AMG S63 4matic Coupe | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2016 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2016 | AMG S65 Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2016 | Maybach S 600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2016 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2016 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2016 | S550 4matic Coupe | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2016 | S550e | Auto 7-spd, 6 cyl, 3.0 L, Turbo | 26 |
| 2016 | S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2015 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2015 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2015 | S550 4matic Coupe | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2015 | S550e | Auto 7-spd, 6 cyl, 3.0 L, Turbo | 26 |
| 2015 | S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2015 | S63 AMG 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2015 | S63 AMG 4matic Coupe | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2015 | S65 AMG | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2015 | S65 AMG Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2014 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2014 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2014 | S63 AMG 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2013 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2013 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2013 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 18 |
| 2013 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 14 |
| 2013 | S63 AMG | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2013 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2012 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2012 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2012 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 18 |
| 2012 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 14 |
| 2012 | S63 AMG | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2012 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2011 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2011 | S550 | Auto 7-spd, 8 cyl, 5.5 L | 18 |
| 2011 | S550 4matic | Auto 7-spd, 8 cyl, 5.5 L | 17 |
| 2011 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 14 |
| 2011 | S63 AMG | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2011 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 14 |
| 2010 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2010 | S550 | Auto 7-spd, 8 cyl, 5.5 L | 18 |
| 2010 | S550 4matic | Auto 7-spd, 8 cyl, 5.5 L | 17 |
| 2010 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 13 |
| 2010 | S63 AMG | Auto 7-spd, 8 cyl, 6.3 L | 14 |
| 2010 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 13 |
Source: fueleconomy.gov.