Which year to buy
Best betNo standoutNo year is clearly better than the rest
Newest we'd buy2024The latest year rated a good buy
Avoid2022Far more serious problems than usual
Be careful2021More problems; check the recalls were done
Bar height: serious owner complaints to NHTSA for that year per car on the road, against this model's usual year.
2010GOOD BUYSerious complaints 0.9× usual
25 serious complaints of 34, the most about fuel system (7) and suspension (7); per car on the road, 0.9× this model's usual year.
What owners report
“Vehicle garaged in storage for summer. Upon returning strong odor of gasoline was detected. Reluctantly drove to dealership and prognoses was determined that (fuel pump strainer) had malfunction thus soaking the entire rear passenger compartment and seat cushion.”
An owner's complaint to NHTSA about the fuel system, Nov 2022
“Airmatic Suspension sprung a leak and could not be driven safely due to the vehicle getting severely low where the tire and rim tucked into the wheel well.”
An owner's complaint to NHTSA about the suspension, Aug 2022
34 owner complaints · 0 recalls · EPA combined: 13–21 mpg · NHTSA: Not rated · 2010 trims and features
Every S-Class year's verdict →
Verdicts computed from NHTSA owner complaints, defect investigations and recalls. Cars on the road from New York State registrations. (How we judge.) Data checked 2026-10-06.
Trims and features
Engines: 3.5L 6-cyl hybrid; 5.5L 12-cyl turbo; 5.5L 8-cyl; 6.0L 12-cyl turbo; 6.3L 8-cyl · Drive: 4WD, RWD
2010 S-Class trims
| S400 Hybrid | S550 | S550 4-MATIC | S600Bi-T | S63 AMG | S65 AMG |
|---|
base price, seating and driver-assistance equipment from NHTSA's vehicle database (vPIC), as Mercedes-Benz reports it. Tech and comfort features (CarPlay, heated seats, sunroof) for Mercedes-Benz aren't in our data yet. "—": not verified in our sources. "Varies": standard on some versions of the trim.
Year by year
| Year | Engines | Drive | Fuel economy | Crash rating | Recalls | Owner complaints | Most-reported problem | CarPlay |
|---|---|---|---|---|---|---|---|---|
| 2024 | 3.0L 6-cyl turbo + supercharged, 362–443 hp 4.0L 8-cyl turbo, 496–604 hp 6.0L 12-cyl turbo, 621 hp | AWD | 15–24 mpg | Not rated | 0 | 6 | Electrical system (2) | — |
| 2023 | 3.0L 6-cyl, 362–429 hp 3.0L 6-cyl turbo, 362–429 hp 4.0L 8-cyl turbo, 496–603 hp 6.0L 12-cyl turbo, 621 hp | AWD | 14–23 mpg | Not rated | 0 | 12 | Forward collision avoidance (5) | — |
| 2022 | 3.0L 6-cyl, 362–429 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | AWD | 15–24 mpg | Not rated | 0 | 48 | Forward collision avoidance (17) | — |
| 2021 | 3.0L 6-cyl, 362–429 hp 4.0L 8-cyl turbo, 463–603 hp | 4WD, RWD | 17–24 mpg | Not rated | 0 | 34 | Electrical system (10) | — |
| 2020 | 3.0L 6-cyl turbo, 362 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | 4WD, RWD | 16–23 mpg | Not rated | 1 | 8 | Unknown or other (2) | — |
| 2019 | 3.0L 4-cyl turbo, 362 hp 3.0L 6-cyl turbo, 362 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | 4WD, FWD, RWD | 16–23 mpg | Not rated | 1 | 18 | Unknown or other (5) | — |
| 2018 | 3.0L 6-cyl turbo, 362 hp 4.0L 8-cyl turbo, 463–603 hp 6.0L 12-cyl turbo, 621 hp | 4WD, FWD, RWD | 16–22 mpg | Not rated | 1 | 33 | Engine (7) | — |
| 2017 | 3.0L 6-cyl turbo 4.7L 8-cyl turbo, 449 hp 5.5L 8-cyl turbo, 577 hp 6.0L 12-cyl turbo, 621 hp | 4WD, RWD | 16–26 mpg | Not rated | 0 | 22 | Unknown or other (4) | — |
| 2016 | 3.0L 6-cyl turbo 4.7L 8-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 15–26 mpg | Not rated | 0 | 29 | Unknown or other (13) | — |
| 2015 | 3.0L 6-cyl turbo 4.7L 8-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 15–26 mpg | Not rated | 0 | 51 | Unknown or other (10) | — |
| 2014 | 4.7L 8-cyl turbo 5.5L 8-cyl turbo | 4WD, RWD | 18–20 mpg | Not rated | 0 | 25 | Unknown or other (5) | — |
| 2013 | 3.5L 6-cyl hybrid 4.7L 8-cyl turbo 5.5L 12-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 14–21 mpg | Not rated | 0 | 9 | Electrical system (2) | — |
| 2012 | 3.5L 6-cyl hybrid 4.7L 8-cyl turbo 5.5L 12-cyl turbo 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 14–21 mpg | Not rated | 0 | 14 | Engine (7) | — |
| 2011 | 3.5L 6-cyl hybrid 5.5L 12-cyl turbo 5.5L 8-cyl 5.5L 8-cyl turbo 6.0L 12-cyl turbo | 4WD, RWD | 14–21 mpg | Not rated | 0 | 19 | Fuel/propulsion system (4) | — |
| 2010 | 3.5L 6-cyl hybrid 5.5L 12-cyl turbo 5.5L 8-cyl 6.0L 12-cyl turbo 6.3L 8-cyl | 4WD, RWD | 13–21 mpg | Not rated | 0 | 34 | Electrical system (10) | — |
Owner complaints are unverified reports to NHTSA, counted as filed: older years have had longer to collect them and sales aren't adjusted for, so see Which year to buy for a fair comparison. Most-reported problem: the component named in the most complaints that year. Sources: EPA, NHTSA, Apple.
Which years have…
Wireless Apple CarPlayApple CarPlay (wired or wireless)Wireless phone chargingHead-up displayPower liftgateLane centeringBlind-spot monitoringHeated front seatsVentilated (cooled) seatsHeated steering wheelLeather seatsRemote startSunroof or moonroofPanoramic roof
Every NHTSA-rated version: crash ratings, safety tech, recalls, complaints
| Year | Version | Stars | Forward collision warning | Lane departure warning | Recalls | Complaints |
|---|---|---|---|---|---|---|
| 2024 | Mercedes-Benz S-Class 4 DR AWD | Not Rated | Standard | Standard | 3 | 6 |
| 2024 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Standard | 3 | 6 |
| 2024 | Mercedes-Benz S-Class PHEV 4 DR AWD | Not Rated | Standard | Standard | 2 | 6 |
| 2023 | Mercedes-Benz Mercedes-Maybach S-Class 4 DR AWD | Not Rated | Standard | Standard | 9 | 11 |
| 2023 | Mercedes-Benz S-Class 4 DR AWD | Not Rated | Standard | Standard | 10 | 12 |
| 2023 | Mercedes-Benz S-Class Hybrid 4 DR AWD | Not Rated | Standard | Standard | 8 | 3 |
| 2022 | Mercedes-Benz Mercedes-Maybach S-Class 4 DR 4WD | Not Rated | Standard | No | 10 | 47 |
| 2022 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | No | 11 | 48 |
| 2022 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | No | 11 | 48 |
| 2021 | Mercedes-Benz S-Class 2 DR RWD | Not Rated | Standard | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | Standard | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | No | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class Cabriolet C RWD | Not Rated | Standard | No | 17 | 34 |
| 2021 | Mercedes-Benz S-Class Cabriolet C 4WD | Not Rated | Standard | No | 17 | 34 |
| 2020 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class 2 DR RWD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class Cabriolet C 4WD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class Cabriolet C RWD | Not Rated | No | No | 7 | 7 |
| 2020 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | No | No | 4 | 5 |
| 2019 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class 2 DR RWD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class Cabriolet C 4WD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S-Class Cabriolet C RWD | Not Rated | Standard | Optional | 14 | 16 |
| 2019 | Mercedes-Benz S560e 4 DR RWD | Not Rated | Standard | Optional | 10 | 9 |
| 2018 | Mercedes-Benz S-Class C RWD | Not Rated | Optional | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class C 4WD | Not Rated | Optional | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class Coupe 2 DR 2WD | Not Rated | Optional | Optional | 15 | 29 |
| 2018 | Mercedes-Benz S-Class Coupe 2 DR 4WD | Not Rated | Optional | Optional | 15 | 29 |
| 2017 | Mercedes-Benz S-Class C RWD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class C 4WD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class Hybrid 4 DR 4WD | Not Rated | Optional | Optional | 10 | 22 |
| 2017 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Optional | Optional | 10 | 22 |
| 2016 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class 2 DR FWD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class 2 DR 4WD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Optional | Optional | 7 | 29 |
| 2016 | Mercedes-Benz S-Class Hybrid 4 DR 4WD | Not Rated | Optional | Optional | 7 | 29 |
| 2015 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Standard | Optional | 9 | 51 |
| 2015 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Standard | Optional | 9 | 51 |
| 2015 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Standard | Optional | 5 | 11 |
| 2015 | Mercedes-Benz S-Class Hybrid 4 DR 4WD | Not Rated | Standard | Optional | 5 | 11 |
| 2014 | Mercedes-Benz S-CLASS 4 DR 4WD | Not Rated | Standard | Optional | 6 | 25 |
| 2014 | Mercedes-Benz S-CLASS 4 DR RWD | Not Rated | Standard | Optional | 6 | 25 |
| 2013 | Mercedes-Benz S-Class 4 DR 4WD | Not Rated | Optional | Optional | 0 | 9 |
| 2013 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 0 | 9 |
| 2013 | Mercedes-Benz S-Class Hybrid 4 DR RWD | Not Rated | Optional | No | 0 | 9 |
| 2012 | Mercedes-Benz S-Class 4 DR AWD | Not Rated | Optional | Optional | 3 | 14 |
| 2012 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | Optional | Optional | 3 | 14 |
| 2011 | Mercedes-Benz S-Class 4 DR RWD | Not Rated | No | No | 2 | 19 |
| 2010 | Mercedes-Benz S-Class 4-DR w/SAB | Not Rated | Optional | Optional | 0 | 34 |
Source: NHTSA.
Every EPA-rated version: engines and combined mpg
| Year | EPA model | Engines | Combined |
|---|---|---|---|
| 2024 | Maybach S680 4matic | Auto 9-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2024 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo, Sup Charg | 24 |
| 2024 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2024 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2023 | Maybach S680 4matic | Auto 9-spd, 12 cyl, 6.0 L, Turbo | 14 |
| 2023 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L | 23 |
| 2023 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2023 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2023 | S580e 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 23 |
| 2022 | Maybach S680 4matic | Auto 9-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2022 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L | 24 |
| 2022 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2022 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2021 | AMG S63 4matic Plus Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 17 |
| 2021 | AMG S63 4matic Plus Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2021 | S500 4matic | Auto 9-spd, 6 cyl, 3.0 L | 24 |
| 2021 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2021 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2021 | S580 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2021 | S580 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2020 | AMG S63 4matic Plus | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | AMG S63 4matic Plus Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2020 | AMG S63 4matic Plus Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2020 | Maybach S650 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2020 | S450 | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2020 | S450 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2020 | S560 | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2020 | S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2020 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | S560 4matic Maybach | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2020 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2020 | S560e | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 23 |
| 2019 | AMG S63 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | AMG S63 4matic Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2019 | AMG S63 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | AMG S65 Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | AMG S65 Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | Maybach S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2019 | Maybach S650 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2019 | S450 | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2019 | S450 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2019 | S560 | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2019 | S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2019 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2019 | S560e | Auto 9-spd, 4 cyl, 3.0 L, Turbo | 23 |
| 2018 | AMG S63 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2018 | AMG S63 4matic Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 18 |
| 2018 | AMG S63 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2018 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | AMG S65 Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | AMG S65 Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | Maybach S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 19 |
| 2018 | Maybach S650 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2018 | S450 | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2018 | S450 4matic | Auto 9-spd, 6 cyl, 3.0 L, Turbo | 22 |
| 2018 | S560 | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2018 | S560 4matic | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2018 | S560 4matic Coupe | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 21 |
| 2018 | S560 Convertible | Auto 9-spd, 8 cyl, 4.0 L, Turbo | 20 |
| 2017 | AMG S63 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2017 | AMG S63 4matic Convertible | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 17 |
| 2017 | AMG S63 4matic Coupe | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2017 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | Maybach S550 4matic | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2017 | Maybach S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | Maybach S650 Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | S550 | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 21 |
| 2017 | S550 4matic | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2017 | S550 4matic Coupe | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2017 | S550 Convertible | Auto 9-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2017 | S550e | Auto 7-spd, 6 cyl, 3.0 L, Turbo | 26 |
| 2017 | S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | S65 AMG Convertible | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2017 | S65 AMG Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2016 | AMG S63 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2016 | AMG S63 4matic Coupe | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2016 | AMG S65 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2016 | AMG S65 Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2016 | Maybach S 600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2016 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2016 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2016 | S550 4matic Coupe | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2016 | S550e | Auto 7-spd, 6 cyl, 3.0 L, Turbo | 26 |
| 2016 | S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2015 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2015 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2015 | S550 4matic Coupe | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2015 | S550e | Auto 7-spd, 6 cyl, 3.0 L, Turbo | 26 |
| 2015 | S600 | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 16 |
| 2015 | S63 AMG 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2015 | S63 AMG 4matic Coupe | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2015 | S65 AMG | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2015 | S65 AMG Coupe | Auto 7-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2014 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 20 |
| 2014 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2014 | S63 AMG 4matic | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2013 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2013 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2013 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 18 |
| 2013 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 14 |
| 2013 | S63 AMG | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2013 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2012 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2012 | S550 | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 19 |
| 2012 | S550 4matic | Auto 7-spd, 8 cyl, 4.7 L, Turbo | 18 |
| 2012 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 14 |
| 2012 | S63 AMG | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2012 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 15 |
| 2011 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2011 | S550 | Auto 7-spd, 8 cyl, 5.5 L | 18 |
| 2011 | S550 4matic | Auto 7-spd, 8 cyl, 5.5 L | 17 |
| 2011 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 14 |
| 2011 | S63 AMG | Auto 7-spd, 8 cyl, 5.5 L, Turbo | 18 |
| 2011 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 14 |
| 2010 | S400 Hybrid | Auto 7-spd, 6 cyl, 3.5 L | 21 |
| 2010 | S550 | Auto 7-spd, 8 cyl, 5.5 L | 18 |
| 2010 | S550 4matic | Auto 7-spd, 8 cyl, 5.5 L | 17 |
| 2010 | S600 | Auto 5-spd, 12 cyl, 5.5 L, Turbo | 13 |
| 2010 | S63 AMG | Auto 7-spd, 8 cyl, 6.3 L | 14 |
| 2010 | S65 AMG | Auto 5-spd, 12 cyl, 6.0 L, Turbo | 13 |
Source: fueleconomy.gov.